Cancer Gene Therapy

Research from Central South University has provided new information about cancer gene therapy

Published in Gene Therapy Weekly, June 4th, 2009

"Gene therapy provides a promising approach for cancer treatment. Earlier studies suggested that poly-L-lysine-modified iron oxide nanoparticles (IONP-PLL) might be a promising gene delivery system that can transfect DNA efficiently in vitro and in vivo," scientists writing in the journal Cancer Gene Therapy report.

"In this study we used IONP-PLL as gene carriers to deliver the NM23-H1 gene, the first suppressor gene of cancer metastasis, to tumor cells in vivo. The intravenous injection of IONP-PLL carrying NM23-H1-GFP plasmid DNA significantly extended the survival time of an experimental pulmonary metastasis mouse model. In the IONP-PLL/NM23-H1-GFP-treated...

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Source: Gene Therapy Weekly (2009-06-04)

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