Small Cell Lung Cancer

Researchers at Fourth Military Medical University publish new data on small cell lung cancer

Published in Gene Therapy Weekly, June 11th, 2009

"The goal of this study was to evaluate the effect of the Na+/H+ exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer (SCLC) cell proliferation and apoptosis. A recombinant NHE-1 antisense gene was transfected into drug-resistant human SCLC H446/CDDP cells," scientists in Xian, People's Republic of China report.

"Intracellular PH (pHi) was measured with fluorescence spectrophotometry. Cell proliferation was assayed cytometrically, and expression of the apoptosis gene caspase-3 was assayed using immunohistochemistry. Apoptosis and the cell cycles were imaged using a flow cytometer. pHi decreased significantly in transfected cells compared...

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Source: Gene Therapy Weekly (2009-06-11)

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