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Gene Therapy
Scientists at University of Turin discuss research in gene therapy
June 18th, 2009
"The identification of direct targets of transcription factors is a key problem in the study of gene regulatory networks. However, the use of high throughput experimental methods, such as ChIP-chip and ChIP-sequencing, is limited by their high cost and strong dependence on cellular type and context," researchers in Turin, Italy report. "We developed a computational method for the genome-wide identification of functional transcription factor binding sites based on positional weight matrices, comparative genomics, and gene expression profiling. The method was applied to Stat3, a transcription factor playing crucial roles in inflammation, immunity and oncogenesis, and able...
Source: Gene Therapy Weekly (2009-06-18)
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