Angiogenesis

Findings from University of Pittsburgh provide new insights into angiogenesis

Published in Gene Therapy Weekly, June 18th, 2009

"Arsenic in drinking water is a major public health concern as it increases risk and incidence of cardiovascular disease and cancer. Arsenic exposure affects multiple vascular beds, promoting liver sinusoidal capillarization and portal hypertension, ischemic heart disease, peripheral vascular disease, and tumor angiogenesis," scientists in the United States report.

"While Rac1-GTPase and NADPH oxidase activities are essential for arsenic-stimulated endothelial cell signaling for angiogenesis or liver sinusoid capillarization, the mechanism for initiating these effects is unknown. We found that arsenic-stimulated cell signaling and angiogenic gene expression in human...

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Source: Gene Therapy Weekly (2009-06-18)

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