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Cancer Gene Therapy
New data from X.W. He et al illuminate research in cancer gene therapy
June 18th, 2009
"A nonviral gene carrier, calcium carbonate (CaCO3)-nanoparticle, was evaluated for the efficient in vitro and in vivo delivery of siRNA-targeting vascular endothelial growth factor-C (VEGF-C). The chemically synthesized CaCO3-nanoparticle has a 58-nm diameter and a + 28.6-mV positive surface charge," researchers in Changsha, People's Republic of China report. "It is capable of forming a CaCO3-nanoparticle-DNA complex and transferring DNA into targeted cells with high transfection efficiency, while effectively protecting the encapsulated DNA from degradation. Further, the CaCO3-nanoparticle-DNA complex has no obvious cytotoxicity for LoVo cells, while a liposome-DNA...
Source: Gene Therapy Weekly (2009-06-18)
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