Atherosclerosis
New findings from University of Wisconsin, Medical Department in the area of atherosclerosis published
Published in Gene Therapy Weekly, June 25th, 2009
In this recent report, researchers in the United States conducted a study "To characterize and compare primary and restenotic lesions of the superficial femoral artery and analyze the contribution of TGF-beta/Smad3 signaling to the pathophysiology of peripheral artery occlusive disease. Immunohistochemical studies were performed on specimens retrieved from the superficial femoral artery of patients undergoing either atherectomy for primary atherosclerotic or recurrent disease after stenting and/or prior angioplasty."
"Immunohistochemical analysis revealed a significantly higher smooth muscle cell (SMC) content (alpha-actin+) and expression of Smad3 in restenotic lesions...
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Source: Gene Therapy Weekly (2009-06-25)
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