Fibrosarcoma
Reports outline fibrosarcoma study results from Stanford University, Medical Department
Published in Gene Therapy Weekly, July 2nd, 2009
According to recent research published in the Journal of Cell Science, "Previously, we related fibronectin (Fn1) mRNA translation to an interaction between an AU-rich element in the Fn1 3' UTR and light chain 3 (LC3) of microtubule-associated proteins 1A and 1B. Since human fibrosarcoma (HT1080) cells produce little fibronectin and LC3, we used these cells to investigate how LC3-mediated Fn1 mRNA translation might alter tumor growth."
"Transfection of HT1080 cells with LC3 enhanced fibronectin mRNA translation. Using polysome analysis and RNA-binding assays, we show that elevated levels of translation depend on an interaction between a triple arginine motif in...
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Source: Gene Therapy Weekly (2009-07-02)
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