Mesothelioma

Data from University of Lille provide new insights into mesothelioma

Published in Gene Therapy Weekly, July 2nd, 2009

According to a study from Lille, France, " Previous data suggested that serum levels of soluble mesothelin (SM) are related to tumor size and may have prognostic significance in malignant pleural mesothelioma (MPM). We tested the hypothesis that this marker could also be useful for monitoring response to treatment."

"Serial measurements of SM were determined in 40 patients diagnosed with MPM and subjected to gene-transfer therapy using intrapleural infusion of an adenoviral vector expressing human IFN-beta or conventional treatment (mainly chemotherapy). In patients with baseline SM levels greater than 1 nM/L and disease progression after therapy, SM levels increased by...

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Source: Gene Therapy Weekly (2009-07-02)

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