Apoptosis

New apoptosis study findings have been reported by researchers at INSERM

Published in Gene Therapy Weekly, July 2nd, 2009

According to a study from Toulouse, France, "Apoptosis is a highly organized, energy-dependent program by which multicellular organisms eliminate damaged, superfluous, and potentially harmful cells. Although caspases are the most prominent group of proteases involved in the apoptotic process, the role of lysosomes has only recently been unmasked."

"This study investigated the role of the lysosomal serine protease CLN2 in apoptosis. We report that cells isolated from patients affected with late infantile neuronal ceroid lipofuscinosis (LINCL) having a deficient activity of CLN2 are resistant to the toxic effect of death ligands such as tumor necrosis factor (TNF), CD95...

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Source: Gene Therapy Weekly (2009-07-02)

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