Melanoma Gene Therapy

Scientists at National Institutes of Health target melanoma gene therapy

Published in Gene Therapy Weekly, July 2nd, 2009

A report, 'Wnt5A activates the calpain-mediated cleavage of filamin A,' is newly published data in Journal of Investigative Dermatology. According to recent research from the United States, "We have previously shown that Wnt5A and ROR2, an orphan tyrosine kinase receptor, interact to mediate melanoma cell motility. In other cell types, this can occur through the interaction of ROR2 with the cytoskeletal protein filamin A."

"Here, we found that filamin A protein levels correlated with Wnt5A levels in melanoma cells. Small interfering RNA (siRNA) knockdown of WNT5A decreased filamin A expression. Knockdown of filamin A also corresponded to a decrease in melanoma...

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Source: Gene Therapy Weekly (2009-07-02)

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