DNA Research

Researchers from University of Massachusetts detail findings in DNA research

Published in Gene Therapy Weekly, July 2nd, 2009

According to a study from the United States, "In response to DNA damage, eukaryotic cells initiate a complex signalling pathway, termed the DNA damage response (DDR), which coordinates cell cycle arrest with DNA repair. Studies have shown that oncogene-induced senescence, which provides a barrier to tumour development, involves activation of the DDR1-3."

"Using a genome-wide RNA interference (RNAi) screen, we have identified 17 factors required for oncogenic BRAF to induce senescence in primary fibroblasts and melanocytes(4). One of these factors is an F-box protein, FBXO31, a candidate tumour suppressor encoded in 16q24.3, a region in which there is loss of...

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Source: Gene Therapy Weekly (2009-07-02)

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