Gene Therapy Weekly
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Gene Therapy
New findings from L.J. Shao and co-researchers in the area of gene therapy described
July 9th, 2009
According to recent research published in the journal Cell Research, "Generation of induced pluripotent stem (iPS) cells from somatic cells has been achieved successfully by simultaneous viral transduction of defined reprogramming transcription factors (TFs). However, the process requires multiple viral vectors for gene delivery." "As a result, generated iPS cells harbor numerous viral integration sites in their genomes. This can increase the probability of gene mutagenesis and genomic instability, and present significant barriers to both research and clinical application studies of iPS cells. In this paper, we present a simple lentivirus reprogramming system in...
Source: Gene Therapy Weekly (2009-07-09)
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