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Gene Therapy
Research data from T. Kiyota and colleagues update understanding of gene therapy
July 9th, 2009
"Accumulation of aggregated amyloid-beta (A beta) peptide was studied as an initial step for Alzheimer's disease (AD) pathogenesis. Following amyloid plaque formation, reactive microglia and astrocytes accumulate around plaques and cause neuroinflammation," researchers in the United States report. "Here brain chemokines play a major role for the glial accumulation. We have previously shown that transgenic overexpression of chemokine CCL2 in the brain results in increased microglial accumulation and diffuse amyloid plaque deposition in a transgenic mouse model of AD expressing Swedish amyloid precursor protein (APP) mutant. Here, we report that adeno-associated virus...
Source: Gene Therapy Weekly (2009-07-09)
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