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Angiogenesis
Data from University of Connecticut advance knowledge in angiogenesis
July 9th, 2009
According to a study from the United States, "Gene transfer of FGF1 has been demonstrated to successfully promote angiogenesis. NV1FGF, a novel pCOR (conditional origin of replication) DNA plasmid-based gene delivery system, is in development by sanofi-aventis for the local expression of FGF1 in the treatment of peripheral vascular disease, and has demonstrated potential to induce therapeutic angiogenesis." "Preclinical studies using NV1FGF demonstrated restoration in capillary and arteriolar density in rabbit and hamster models of hind limb ischemia. In phase I and phase II clinical trials, NV1FGF effectively reduced the number of amputations and deaths in the trials,...
Source: Gene Therapy Weekly (2009-07-09)
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