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Breast Cancer
Study results from J. Lin and colleagues in the area of breast cancer published
July 9th, 2009
"Four and a half LIM domains 1 (FHL1) belongs to a family of LIM-only proteins that regulate gene transcription, cell proliferation, differentiation and apoptosis. However, the biological function of FHL1 remains largely unknown," scientists in Beijing, People's Republic of China report. "We used a yeast two-hybrid system and identified receptor interacting protein of 140 kDa (RIP140) as a novel FHL1-binding protein. RIP140 interacted with FHL1 both in vitro and in mammalian cells and estrogen enhanced this interaction. All domains of FHL1 are required to interact with RIP140. Overexpression of FHL1 enhanced RIP140 repression of estrogen signaling in breast cancer cells...
Source: Gene Therapy Weekly (2009-07-09)
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