Antisense Technology

Reports from University of Pittsburgh add new data to research in antisense technology

Published in Gene Therapy Weekly, July 9th, 2009

" Squamous cell carcinoma of the head and neck (SCCHN) is characterized by upregulation of the epidermal growth factor receptor ( EGFR). We developed a novel strategy to target EGFR by using a therapeutic gene that consisted of an EGFR antisense (AS) gene sequence under U6 promoter control," researchers in the United States report.

"A phase I clinical trial was conducted to evaluate the safety and biologic effects of EGFR AS. Patients and Methods Patients with advanced SCCHN who were refractory to standard therapies and who had at least one assessable and accessible lesion were enrolled. The EGFR AS dose was escalated in successive cohorts (six dose levels; 60 to 1,920...

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Source: Gene Therapy Weekly (2009-07-09)

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