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Emphysema
Research from Osaka University has provided new information about emphysema
July 9th, 2009
"1,6-Fucosylation plays key roles in many biological functions, as evidenced by the study of 1,6-fucosyltransferase (Fut8) knockout (Fut8(/)) mice. Phenotypically, Fut8(/) mice exhibit emphysema-like changes in the lung, and severe growth retardation," scientists in Suita, Japan report. "Fut8(/) cells also show marked dysregulation of the TGF-1 receptor, EGF receptor, integrin activation and intracellular signalling, all of which can be rescued by reintroduction of Fut8. The results of the present study demonstrated that vascular endothelial growth factor receptor-2 (VEGFR-2) expression was significantly suppressed in Fut8(/) mice, suggesting that Fut8 was required for...
Source: Gene Therapy Weekly (2009-07-09)
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