Gene Therapy

New gene therapy study results reported from Baylor College of Medicine, College of Medicine

Published in Gene Therapy Weekly, July 16th, 2009

According to recent research from the United States, "Glis3 is a member of the Krppel-like family of transcription factors and is highly expressed in islet cells. Mutations in GLIS3 cause the syndrome of neonatal diabetes and congenital hypothyroidism (NDH)."

"Our aim was to examine the role of Glis3 in cells, specifically with regard to regulation of insulin gene transcription. We demonstrate that insulin 2 (Ins2) mRNA expression in rat insulinoma 832/13 cells is markedly increased by wild-type Glis3 overexpression, but not by the NDH1 mutant. Furthermore, expression of both Ins1 and Ins2 mRNA is downregulated when Glis3 is knocked down by siRNA. Glis3 binds to the...

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Source: Gene Therapy Weekly (2009-07-16)

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