Cancer Gene Therapy
New cancer gene therapy study findings reported from University of Bologna
Published in Gene Therapy Weekly, July 16th, 2009
"The highly aggressive cancer syndrome of female mice carrying a p53 knockout allele and a rat HER-2/neu (Neu) transgene (BALB-p53Neu) can be prevented by a cell vaccine presenting three components: Neu, interleukin (IL)-12 production, and allogeneic major histocompatibility complex (MHC) alleles (Triplex cell vaccine). Here we tested a second-generation Triplex DNA-based vaccine (Tri-DNA), consisting of the combination of three gene components (a transmembrane -extracellular domain fragment of the Neu gene, IL-12 genes, and the H-2D(q) allogeneic MHC gene), carried by separate plasmids," researchers in Bologna, Italy report.
"The Tri-DNA vaccine was at least as...
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Source: Gene Therapy Weekly (2009-07-16)
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