Gene Therapy
Researchers from Leiden University detail new studies and findings in the area of gene therapy
Published in Gene Therapy Weekly, July 23rd, 2009
"Adaptation to stress in vertebrates occurs via activation of hormonal and neuronal signaling cascades in which corticotropin-releasing hormone (CRH) plays a central role. Expression of brain CRH is subject to strong, brain-region specific regulation by glucocorticoid hormones and neurogenic intracellular signals," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report.
"We hypothesized that Steroid Receptor Coactivator 1 (SRC-1), a transcriptional coregulator of the glucocorticoid receptor, is involved in the sensitivity of CRH regulation by stress-related factors. In the brains of SRC-1 knockout...
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Source: Gene Therapy Weekly (2009-07-23)
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