Life Sciences
Researchers from Cancer Research UK London Research Institute describe findings in life sciences
Published in Gene Therapy Weekly, July 23rd, 2009
New investigation results, 'PIKfyve regulation of endosome-linked pathways,' are detailed in a study published in Traffic. According to recent research from London, the United Kingdom, "The phosphoinositide 5-kinase (PIKfyve) is a critical enzyme for the synthesis of PtdIns(3,5)P2, that has been implicated in various trafficking events associated with the endocytic pathway. We have now directly compared the effects of siRNA-mediated knockdown of PIKfyve in HeLa cells with a specific pharmacological inhibitor of enzyme activity."
"Both approaches induce changes in the distribution of CI-M6PR and trans-Golgi network (TGN)-46 proteins, which cycles between endosomes...
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Source: Gene Therapy Weekly (2009-07-23)
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