Foamy Virus

Researchers from University of Wurzburg report on findings in foamy virus

Published in Gene Therapy Weekly, August 6th, 2009

According to recent research published in the journal Retrovirology, "Foamy viruses (FVs) are the most genetically stable viruses of the retrovirus family. This is in contrast to the in vitro error rate found for recombinant FV reverse transcriptase (RT)."

"To investigate the accuracy of FV genome copying in vivo we analyzed the occurrence of mutations in HEK 293T cell culture after a single round of reverse transcription using a replication-deficient vector system. Furthermore, the frequency of FV recombination by template switching (TS) and the cross-packaging ability of different FV strains were analyzed. We initially sequenced 90,000 nucleotides and detected...

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Source: Gene Therapy Weekly (2009-08-06)

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