Published in Gene Therapy Weekly, August 13th, 2009
"Thus NHEJ functions independently of ATM signalling. However, similar to 15% of radiation-induced DSBs are repaired with slow kinetics and require ATM and the nuclease Artemis. DSBs persisting in the presence of an ATM inhibitor, ATMi, localize to heterochromatin, suggesting that ATM is required for repairing DSBs arising within or close to...
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