Cancer Gene Therapy
Researchers at Third Military Medical University target cancer gene therapy
Published in Gene Therapy Weekly, August 13th, 2009
According to recent research from Chongqing, People's Republic of China, "To observe whether cyclin D1 siRNA-mediated inhibition of cyclin D1 represents a promising antigrowth and antimetastatic strategy for cancer gene therapy, particularly for non-small cell lung cancers. To stably transfect the A549 cell line with a cyclin D1-targeted siRNA to downregulate cyclin D1 expression and observe the effects on protein expression, and tumor growth in vitro and in vivo."
"Expression of cyclin D1-targeted siRNA resulted in a decrease in cyclin D1, MMP-2, RhoA, and Rac1 protein levels, as detected by Western blot and immunofluorescence studies. Transfected cells also exhibited...
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Source: Gene Therapy Weekly (2009-08-13)
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