Phosphatase

Scientists at Chinese Academy of Sciences publish new data on phosphatase

Published in Gene Therapy Weekly, August 13th, 2009

Scientists discuss in 'Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration' new findings in phosphatase. "Trophoblast invasion is crucial for embryo implantation and placentation. Excessive trophoblast invasion leads to hydatidiform moles and choriocarcinoma," scientists in Beijing, People's Republic of China report.

"PPM1A is a phosphatase which dephosphorylates and inactivates a broad range of substrates, including TGF-beta, MAP kinases, p38 and JNK kinase cascades, and is involved in tumor suppression. The objective of this study was to investigate the expression of PPM1A in normal and malignant human placenta and its role...

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Source: Gene Therapy Weekly (2009-08-13)

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