Life Sciences

Findings in life sciences reported from University of Leipzig, Institute of Clinical Immunology and Transfusion Medicine

Published in Gene Therapy Weekly, August 20th, 2009

Scientists discuss in 'Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells' new findings in life sciences. According to a study from Germany, "Signal transducer and activator of transcription 3 (Stat3) is the major mediator of interleukin-6 (IL-6) family cytokines. In addition, Stat3 is known to be involved in the pathophysiology of many malignancies."

"Here, we show that the cis-trans peptidyl-prolyl isomerase cyclophilin (Cyp) B specifically interacts with Stat3, whereas the highly related CypA does not. CypB knockdown inhibited the IL-6-induced transactivation potential but not the tyrosine phosphorylation of Stat3. Binding of CypB to...

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Source: Gene Therapy Weekly (2009-08-20)

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