DNA Research
Studies from C. Guynet and colleagues provide new data on DNA research
Published in Gene Therapy Weekly, August 20th, 2009
According to recent research from Toulouse, France, "Target site choice is a complex and poorly understood aspect of DNA transposition despite its importance in rational transposon-mediated gene delivery. Though most transposons choose target sites essentially randomly or with some slight sequence or structural preferences, insertion sequence IS608 from Helicobacter pylori, which transposes using single-stranded DNA, always inserts just 3' of a TTAC tetranucleotide."
"Our results from studies on the IS608 transposition mechanism demonstrated that the transposase recognizes its target site by co-opting an internal segment of transposon DNA and utilizes it for specific...
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Source: Gene Therapy Weekly (2009-08-20)
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