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Gene Therapy

Reports from U. Lewandowska and colleagues advance knowledge in gene therapy

Published in Gene Therapy Weekly, August 27th, 2009

"WWOX is a tumour suppressor gene affected in multiple cancers, especially in breast, prostate and ovary. This gene is located at the chromosomal area 16q23.3-24.1, which was identified as a common chromosomal fragile site FRA16D," investigators in Lodz, Poland report.

"WWOX turned Out to Possess tumour Suppressor features despite the fact that the most basic (classical) way Of tumour suppressor gene inactivation involves both alleles (e.g. through deletions, point Mutations and promoter methylation), which Is very rare event in a case of WWOX, Occurring only in few cell lines. A large number of papers corroborate the phenomenon of correlation between the loss of WWOX...

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