Drug Resistance
Researchers from Peking Union Medical College, Biotechnology Department discuss findings in drug resistance
Published in Gene Therapy Weekly, September 3rd, 2009
New investigation results, 'Suppression of N-Ras by shRNA-expressing plasmid increases sensitivity of HepG2 cells to vincristine-induced growth inhibition,' are detailed in a study published in Cancer Gene Therapy. "Oncogenic ras genes relate to the development of human cancers. In this study, we used a plasmid-mediated short-hairpin RNA (shRNA) targeting N-ras gene to combine with clinical drug vincristine (VCR) for the treatment of human hepatoma cells," investigators in Beijing, People's Republic of China report.
"Our results showed that anti-N-Ras shRNA expression vector (pCSH1-shNR) knocked down the target mRNA and protein. Higher efficacy on growth...
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Source: Gene Therapy Weekly (2009-09-03)
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