Gene Therapy
New gene therapy research from Aarhus University outlined
Published in Gene Therapy Weekly, September 10th, 2009
According to recent research from Aarhus, Denmark, "Gene delivery by human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) is efficient, but genomic integration of the viral DNA is strongly biased toward transcriptionally active loci resulting in an increased risk of insertional mutagenesis in gene therapy protocols. Nonviral Sleeping Beauty (SB) transposon vectors have a significantly safer insertion profile, but efficient delivery into relevant cell/tissue types is a limitation."
"In an attempt to combine the favorable features of the two vector systems we established a novel hybrid vector technology based on SB transposase-mediated insertion of...
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Source: Gene Therapy Weekly (2009-09-10)
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