Gene Therapy

Reports from I.B. Johnsen et al highlight recent research in gene therapy

Published in Gene Therapy Weekly, September 10th, 2009

"Antiviral immune responses are initiated through Toll-like receptors (TLRs) and RIG-I (retinoic acid-inducible gene-I)-like RNA helicases that recognize nucleic acids from distinct viruses. In this study, we show that the tyrosine kinase c-Src participates in antiviral responses induced by the cytoplasmic RNA helicase RIG-I," researchers in Trondheim, Norway report.

"Sendai virus (SV), which is recognized by RIG-I, induced c-Src phosphorylation. Functional impairment of c-Src through chemical inhibition or transient expression of a c-Src kinase-inactive mutant attenuated production of endogenous antiviral proteins after SV infection or after expression of RIG-I or its...

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Source: Gene Therapy Weekly (2009-09-10)

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