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Angiogenesis

Data from A. Ahmad and colleagues advance knowledge in angiogenesis

Published in Gene Therapy Weekly, September 10th, 2009

"Hypoxia, through the hypoxia-inducible transcription factors HIF-1 alpha and HIF-2 alpha(HIFs), induces angiogenesis by up-regulating a common set of angiogenic cytokines. Unlike HIF-1 alpha, which regulates a unique set of genes, most genes regulated by HIF-2 alpha overlap with those induced by HIF-1 alpha," researchers in the United States report.

"Thus, the unique contribution of HIF-2 alpha remains largely obscure. By using adenoviral mutant HIF-1 alpha and adenoviral mutant HIF-2 alpha constructs, where the HIFs are transcriptionally active under normoxic conditions, we show that HIF-2 alpha but not HIF-1 alpha regulates adenosine A(2A) receptor in primary...

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