Enzyme Research

New findings from Uniformed Services University of the Health Sciences describe advances in enzyme research

Published in Gene Therapy Weekly, September 10th, 2009

According to recent research from the United States, "Lysyl oxidase acts as both a matrix modifying enzyme and an oncogene suppressor. It is synthesized as a 50-kDa proenzyme, secreted, and processed into an similar to 30 kDa mature, active enzyme and an 18-kDa propeptide."

"The tumor suppressive effect of lysyl oxidase appears to be exerted within the cell, so the subcellular localization of protein forms was investigated. Propeptide-specific antibody detected 50-kDa proenzyme in cytoplasmic and nuclear extracts of non-transformed mouse fibroblasts, but free 18-kDa propeptide was not detected in any extract. Antibody to epitope near the N-terminus of mature lysyl...

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Source: Gene Therapy Weekly (2009-09-10)

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