Apoptosis
Reports from Uniformed Services University of the Health Sciences advance knowledge in neuroblastoma
Published in Gene Therapy Weekly, September 17th, 2009
"N-acetylaspartate (NAA) is synthesized predominantly in neurons, and brain homogenate subfractionation studies suggest that biosynthesis occurs at both microsomal (cytoplasmic) and mitochondrial sites. We investigated NAA synthesis in SH-SY5Y human neuroblastoma cells using distinct metabolic precursors that are preferentially metabolized in mitochondria and cytoplasm," scientists writing in the journal Neurochemistry International report.
"Incorporation of C-14-aspartate and C-14-malate into NAA was examined in the presence and absence of an inhibitor (aminooxyacetic acid, AOAA) of aspartate aminotransferase (AAT), a central enzyme involved in the biosynthesis...
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Source: Gene Therapy Weekly (2009-09-17)
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