Immunotherapy
Study results from A.B. Delcampo and colleagues in the area of immunotherapy published
Published in Gene Therapy Weekly, September 24th, 2009
According to recent research published in the Scandinavian Journal of Immunology, "Here we report a successful use of a non-replicating adenovirus expressing the wild-type human beta 2m gene in recovery of normal human leucocyte antigen (HLA) class I expression in beta 2m-null cancer cells. Total loss of HLA class I expression in these cell lines is caused by a mutation in beta 2m gene and a loss of heterozygosity in chromosome 15 carrying another copy of that gene."
"Normal HLA class I expression on the tumour cell surface is critical for the successful outcome of cancer immunotherapy as T cells can only recognize tumour-derived peptides in a complex with...
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Source: Gene Therapy Weekly (2009-09-24)
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