Lymphoma Therapy
Investigators at University of Paris have published new data on lymphoma therapy
Published in Gene Therapy Weekly, September 24th, 2009
New investigation results, 'Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells,' are detailed in a study published in Leukemia. "p53 inactivation is often observed in Burkitt's lymphoma (BL) cells, because of either mutations in p53 gene or an overexpression of the p53-negative regulator MDM2. Epstein-Barr virus (EBV) is present in virtually 100% of BL cases occurring in endemic areas, but in only 10-20% of sporadic cases," scientists in Villejuif, France report.
"In EBV(-) BL cells, reactivation of p53, induced by reducing MDM2 protein level, led to apoptosis. We...
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Source: Gene Therapy Weekly (2009-09-24)
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