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Breast Cancer

Research from University of Manitoba in the area of breast cancer published

Published in Gene Therapy Weekly, October 1st, 2009

"Products of the Steroid Receptor RNA Activator gene (SRA1) have the unusual property to modulate the activity of steroid receptors and other transcription factors both at the RNA (SRA) and the protein (SRAP) level. Balance between these two genetically linked entities is controlled by alternative splicing of intron-1, whose retention alters SRAP reading frame," investigators in Winnipeg, Canada report.

"We have previously found that both fully-spliced SRAP-coding and intron-1-containing non-coding SRA RNAs co-exist in breast cancer cell lines. Herein, we report a significant (Students t-test, P 0.003) higher SRAintron-1 relative expression in breast tumors with higher...

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