Enzyme Research

Reports outline enzyme research study results from University of Rochester

Published in Gene Therapy Weekly, October 1st, 2009

According to recent research from the United States, "Activation of RhoA/Rho-associated kinase ( ROCK) pathway and the associated changes in actin cytoskeleton induced by thrombin are crucial for activation of NF-kappa B and expression of its target gene ICAM-1 in endothelial cells. However, the events acting downstream of RhoA/ROCK to mediate these responses remain unclear."

"Here, we show a central role of cofilin-1, an actin-binding protein that promotes actin depolymerization, in linking RhoA/ROCK pathway to dynamic alterations in actin cytoskeleton that are necessary for activation of NF-kappa B and thereby expression of ICAM-1 in these cells. Stimulation of human...

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Source: Gene Therapy Weekly (2009-10-01)

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