Gene Therapy
New gene therapy study findings recently were reported by researchers at University of London, Medical Department
Published in Gene Therapy Weekly, October 8th, 2009
"In human B cells infected with Epstein-Barr virus (EBV), latency-associated virus gene products inhibit expression of the proapoptotic Bcl-2-family member Bim and enhance cell survival. This involves the activities of the EBV nuclear proteins EBNA3A and EBNA3C and appears to be predominantly directed at regulating Bim mRNA synthesis, although post-transcriptional regulation of Bim has been reported," scientists writing in the journal Plos Pathogens report.
"Here we show that protein and RNA stability make little or no contribution to the EBV-associated repression of Bim in latently infected B cells. However, treatment of cells with inhibitors of histone...
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Source: Gene Therapy Weekly (2009-10-08)
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