Adenovirus

Scientists at Children's Hospital detail research in adenovirus

Published in Gene Therapy Weekly, October 8th, 2009

According to a study from the United States, "In cultured cells, infection by group B coxsackievirus (CVB) is mediated by the coxsackievirus and adenovirus receptor (CAR), but the importance of this molecule in CVB-induced disease has not been determined. We generated mice with tissue-specific ablation of CAR within each of two major CVB target organs, the pancreas and heart."

"In the pancreas, deletion of CAR resulted in a significant reduction in both virus titers and virus-induced tissue damage. Similarly, cardiomyocyte-specific CAR deletion resulted in a marked reduction in virus titer, infection-associated cytokine production, and histopathology within the heart....

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Source: Gene Therapy Weekly (2009-10-08)

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