Apoptosis

Studies in the area of apoptosis reported from Jikei University

Published in Gene Therapy Weekly, October 15th, 2009

"Camptothecin derivatives have been widely used for chemotherapy in patients with various cancers, but intrinsic and acquired drug resistance is major drawback to be overcome. In the present study, we demonstrated that simultaneous treatment with camptothecin and valproic acid induced apoptosis of MCF-7 cells, whereas neither agent alone could efficiently induce apoptosis," researchers in Tokyo, Japan report.

"This induction of apoptosis was associated with loss of the mitochondrial membrane potential and was caspase dependent. Further investigation showed that concurrent treatment modulated the expression of pro-apoptotic and anti-apoptotic genes. Bcl-X-L expression...

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Source: Gene Therapy Weekly (2009-10-15)

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