Vascular Endothelial Growth Factor
Scientists at Children's Hospital publish new data on vascular endothelial growth factor
Published in Gene Therapy Weekly, October 15th, 2009
According to recent research from the United States, "Although vascular endothelial growth factor (VEGF) has been shown to act synergistically with bone morphogenetic protein (BMP) 2 and BMP4 to promote ectopic endochondral bone formation via cell-based BMP gene therapy, the optimal ratio of VEGF to either of the BMPs required to obtain this beneficial effect remains unclear. In the current study, two cell types (C2C12, NIH/3T3) were retrovirally transduced to express BMP4 only or both BMP4 and VEGF."
"The resulting groups of cells were tested for their cellular proliferation, in vitro mineralization capacity, survival potential, and ability to undergo ectopic bone...
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Source: Gene Therapy Weekly (2009-10-15)
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