Gastroenterology

Reports outline gastroenterology study findings from Royal Melbourne Hospital

Published in Gene Therapy Weekly, October 15th, 2009

According to recent research from Melbourne, Australia, "Aberrant DNA methylation is a common early event in neoplasia, but it is unclear how this relates to dysregulation of DNA (cytosine-5) methyltransferases (Dnmts). Here we use knock-in transgenic mice to investigate the consequences of intestinal epithelium-specific overexpression of de novo Dnmt3a."

"A novel gene targeting strategy, based on the intestinal epithelium-specific, uniform expression of the A33 glycoprotein, is employed to restrict Dnmt3a overexpression in homozygous A33(Dnmt3a) mutant mice. A33(Dnmt3a) mice infrequently develop spontaneous intestinal polyps. However, when genetically challenged, tumor...

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Source: Gene Therapy Weekly (2009-10-15)

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