Stem Cell Research
Reports outline stem cell research research from D. Hockemeyer and colleagues
Published in Gene Therapy Weekly, October 15th, 2009
According to recent research published in the journal Nature Biotechnology, "Realizing the full potential of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) requires efficient methods for genetic modification. However, techniques to generate cell type-specific lineage reporters, as well as reliable tools to disrupt, repair or overexpress genes by gene targeting, are inefficient at best and thus are not routinely used."
"Here we report the highly efficient targeting of three genes in human pluripotent cells using zinc-finger nuclease (ZFN)-mediated genome editing. First, using ZFNs specific for the OCT4 (POU5F1) locus, we generated...
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Source: Gene Therapy Weekly (2009-10-15)
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