Published in Gene Therapy Weekly, October 15th, 2009
"Previously we made several NfsB mutants that show better activity with CB1954 in a cell-killing assay in E. coli. Here we compare the kinetic parameters of wild-type NfsB with CB1954 to those of the most active single, double, and triple mutants isolated to date. For wild-type NAB the global kinetic parameters for both k(cat) and K-m for CB1954 are about 20-fold higher than previously...
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