Gene Therapy

Study results from Columbia University provide new insights into gene therapy

Published in Gene Therapy Weekly, October 29th, 2009

"In epithelial tissues, the lineage relationship between normal progenitor cells and cell type(s) of origin for cancer has been poorly understood. Here we show that a known regulator of prostate epithelial differentiation, the homeobox gene Nkx3-1, marks a stem cell population that functions during prostate regeneration," scientists writing in the journal Nature report.

"Genetic lineage-marking demonstrates that rare luminal cells that express Nkx3-1 in the absence of testicular androgens (castration-resistant Nkx3-1-expressing cells, CARNs) are bipotential and can self-renew in vivo, and single-cell transplantation assays show that CARNs can reconstitute...

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Source: Gene Therapy Weekly (2009-10-29)

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