Life Sciences

Reports from University of Toronto add new data to research in life sciences

Published in Gene Therapy Weekly, October 29th, 2009

According to recent research published in the journal Molecular Cell, "We describe a fluorescent reporter system that exploits the functional genomic tools available in budding yeast to systematically assess consequences of genetic perturbations on gene expression. We used our Reporter-Synthetic Genetic Array (R-SGA) method to screen for regulators of core histone gene expression."

"We discovered that the histone chaperone Rtt106 functions in a pathway with two other chaperones, Asf1 and the HIR complex, to create a repressive chromatin structure at core histone promoters. We found that activation of histone (HTA1) gene expression involves both relief of...

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Source: Gene Therapy Weekly (2009-10-29)

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