Gene Therapy

Studies from C.M. Lai et al provide new data on gene therapy

Published in Gene Therapy Weekly, November 5th, 2009

In this recent report, researchers in Nedlands, Australia conducted a study "To determine the efficacy of rAAV.sFlt-1-mediated gene therapy in a transgenic mouse model of retinal neovascularization (trVEGF029) and to assess whether rAAV.sFlt-1 administration generated any deleterious, long-lasting immune response that could affect efficacy. trVEGF029 mice were injected subretinally with rAAV.sFlt-1 or phosphate-buffered saline."

"Fluorescein angiography and electroretinography were used to compare the extent of fluorescein leakage from retinal vessels and retinal function, respectively. A group of eyes was enucleated, and the retinal vasculature and morphology were...

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Source: Gene Therapy Weekly (2009-11-05)

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