Cancer Gene Therapy Genetics
Chiba Cancer Center Research Institute describes research in cancer gene therapy genetics
Published in Gene Therapy Weekly, November 5th, 2009
Fresh data on cancer gene therapy are presented in the report 'Cytotoxicity of adenoviruses expressing the wild-type p53 gene to esophageal carcinoma cells is linked with the CAR expression level and indirectly with the endogenous p53 status.' According to recent research from Chiba, Japan, "We examined cytotoxic effects of adenoviruses (Ad) expressing the p53 gene (Ad-p53) in nine human esophageal carcinoma cell lines with respect to the Ad receptor expression and the endogenous p53 gene status. Ad-p53-mediated cytotoxicity was related with an expression level of the coxsackievirus adenovirus receptor (CAR) but not with that of CD51, both of which are type 5 Ad receptors."
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Source: Gene Therapy Weekly (2009-11-05)
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