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Adenocarcinoma

Studies from University of Halle-Wittenberg yield new data on adenocarcinoma

Published in Gene Therapy Weekly, November 12th, 2009

"Transforming growth factor-beta 1 (TGF-beta 1) is over-expressed in a variety of malignant epithelial tumors and was suggested to be a marker of colorectal cancer. Moreover, there is growing evidence that TGF-beta 1 contributes to tumor progression by regulating tumor cell proliferation and differentiation, inducing a favorable tumor microenvironment, promoting migration and invasion, and suppressing macrophage cytotoxicity," scientists in Halle, Germany report.

"Therefore, we stably transfected an anti-TGF-beta 1 hammerhead ribozyme into the human colorectal adenocarcinoma cell line HRT-18. Expression of this ribozyme resulted in significant inhibition of TGF-beta 1...

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